For a full list of publications, check here.

60. Ortiz, G.; Liu, P.; Deal, P. E.; Nensel, A. K.; Martinez, K. N.; Shamardani, K.; Adesnik, H.; Miller, E. W.; A Silicon-Rhodamine Chemical-Genetic Hybrid for Far Red Voltage Imaging from Defined Neurons in Brain Slice. RSC Chem Biol. 2021, 2, 1594-1599. DOI: 10.1039/d1cb00156f. [html]

59. Kulkarni, R. U.; Gest, A. M. M.; Lam, C. K.; Raliski, B. K.; James, F.; Adil, M. M.; Schaffer, D. V.; Wang, Y.; Miller, E. W. Computationally Assisted Design of High Signal-to-Noise Photoinduced Electron Transfer-Based Voltage-Sensitive Dyes. ChemRxiv. Preprint. DOI: 10.26434/chemrxiv.12401753.v1. [html]

58. Lee S.; Chung, C. Y.; Liu, P.; Craciun, L.; Nishikawa, Y.; Bruemmer, K. J.; Hamachi, I.; Saijo, K.; Miller, E. W.; Chang, C. J. Activity-Based Sensing with a Metal-Directed Acyl Imidazole Strategy Reveals Cell Type-Dependent Pools of Labile Brain Copper. J Am Chem Soc. 2020, 142, 14993-15003. DOI: 10.1021/jacs.0c05727. [pdf] [html]

57. Klimas, A.; Ortiz, G.; Boggess, S. C.; Miller, E. W.; Entcheva, E. Multimodal on-axis platform for all-optical electrophysiology with near-infrared probes in human stem-cell-derived cardiomyocytes. Prog Biophys Mol Biol. 2020, 154, 62-70. DOI: 10.1016/j.pbiomolbio.2019.02.004. [pdf] [html]

56. Ginebaugh, S. P.; Cyphers, E. D.; Lanka, V.; Ortiz, G.; Miller, E. W.; Laghaei, R.; Meriney, S. D. The Frog Motor Nerve Terminal Has Very Brief Action Potentials and Three Electrical Regions Predicted to Differentially Control Transmitter Release. J Neurosci. 2020, 40, 3504-16. DOI: 10.1523/JNEUROSCI.2415-19.2020. [pdf] [html]

55. Kand, D.; Liu, P.; Navarro, M. X.; Fischer, L. J.; Rousso-Noori, L.; Friedmann-Morvinski, D.; Winter, A. H.; Miller, E. W.; Weinstain, R. Water-Soluble BODIPY Photocages with Tunable Cellular Localization. J Am Chem Soc 2020, 142, 4970-4. DOI: 10.1021/jacs.9b13219. [pdf] [html]

54. Liu, P.; Miller, E. W.; Electrophysiology, Unplugged: Imaging Membrane Potential with Fluorescent Indicators. Acc Chem Res 2020, 53, 11-19. DOI: 10.1021/acs.accounts.9b00514. [pdf] [html]

53. Deal, P. E.; Liu, P.; Al-Abdullatif, S. H.; Muller, V. R.; Shamardani, K.; Adesnik, H.; Miller, E.W.; Covalently tethered rhodamine voltage reporters for high speed func-tional imaging in brain tissue. J Am Chem Soc 2020, 142, 614-22. DOI: 10.1021/jacs.9b12265. [pdf] [html]

52. Gonzalez, M. A.; Walker, A. S.; Cao, K. J.; Lazzari-Dean, J. R.; Settineri, N.; Kong, E.-J.; Kramer, R. H.; Miller, E. W.; Voltage imaging with a NIR-absorbing phosphine oxide rhodamine voltage reporter. ChemRxiv. 2019, Preprint: DOI: 10.26434/chemrxiv.10025789.v1. [pdf] [html]

51. Lazzari-Dean, J. R.; Gest, A. M. M.; Miller, E. W.; Optical estimation of absolute membrane potential using fluorescence lifetime imaging. eLife. 2019, 8, e44522. DOI: 10.7554/eLife.44522. [pdf] [html]

FEATURED AS an elife digest.

50. Ohata, J.; Krishnamoorthy, L.; Gonzalez, M. A.; Xiao, T.; Iovan, D. A.; Toste, F. D.; Miller, E. W.; Chang, C. J.; An Activity-Based Methionine Bioconjugation Approach to Developing Proximity-Activated Imaging Reporters. ACS Central Science. 2020, 6, 32-40. [pdf] [html]

49. Franke, J. M.; Raliski, B. K.; Boggess, S. C.; Natesan, D. V.; Koretsky, E. T.; Zhang, P.; Kulkarni, R. U.; Deal, P. E.; Miller, E. W.; BODIPY fluorophores for membrane potential imaging. J Am Chem Soc. 2019, 141, 12824-31. DOI: 10.1021/jacs.9b05912. [pdf] [html]

48. Huebsch, N.; Charrez, B.; Siemons, B. A.; Boggess, S. C.; Wall, S.; Charwat, V.; Jaeger, K.; Montiel, F. L. T.; Jeffreys, N. C.; Deveshwar, N.; Edwards, A.; Serrano, J.; Snuderl, M.; Stahl, A.; Tveito, A.; Miller, E. W.; Healy, K. E.; Metabollically-driven maturation of hiPSC-cell derived heart-on-a-chip. bioRxiv. 2018, Preprint: DOI: 10.1101/485169. [pdf] [html]

47. Kazemipour, A.; Novak, O.; Flickinger, D.; Marvin, J. S.; Abdelfattah, A.; King, J.; Borden, P; Kim, J. J.; Deal, P.E.; Al-Abdullatif, S. H.; Miller, E. W.; Schreiter, E. R.; Druckmann, S.; Svoboda, K.; Looger, L. L.; Podgorski, K.; Kilohertz frame-rate two photon tomography. Nat Methods 2019, 16, 778-86. DOI: 10.1038/s41592-019-0493-9. [pdf] [html]

46. Park, J.; Kuo, Y.; Li, J.; Huang, Y. L.; Miller, E. W.; Weiss, S.; Improved surface functionalization and characterization of membrane targeted semiconductor voltage nanosensors. J Phys Chem Lett 2019, 10, 3906 – 13. DOI: 10.1021/acs.jpclett.9b01258. [pdf] [html]

45. Ortiz, G.; Liu, P.; Naing, S. H. H.; Muller, V. R.; Miller, E. W.; Synthesis of Sulfonated Carbofluoresceins for Voltage Imaging. J Am Chem Soc. 2019, 141, 6631-6638. DOI: 10.1021/jacs.9b01261. [pdf] [html]

FEATURED as a research highlight in THE june 2019 ISSUE OF nature methods. [PDF] [HTML]

44. Hamzeh, H.; Alvarez, L.; Strunker, T.; Kierzek, M.; Brenker, C.; Deal, P. E.; Miller, E. W.; Seifert, R.; Kaupp, U. B.; Kinetic and photonic techniques to study chemotactic signaling in sea urchin sperm. Methods Cell Biol. 2019, 151, 487-517. DOI: 10.1016/bs.mcb.2018.12.001. [pdf] [html]

43. Klimas, A.; Ortiz, G.; Boggess, S. C.; Miller, E. W.; Entcheva, E.; Multimodal on-axis platform for all-optical electrophysiology with near-infrared probes in human stem-cell-derived cardiomyocytes. Prog Biophys Mol Biol. 2019, pii, S0079-6107(18)30279-7. DOI: 10.1016/j.pbiomolbio.2019.02.004. [pdf] [html]

42. Boggess, S. C.; Gandhi, S. S.; Siemons, B. A.; Huebsch, N.; Healy, K. E.; Miller, E. W.; New Molecular Scaffolds for Fluorescent Voltage Indicators. ACS Chem Biol. 2019, 14, 390-396. DOI: 10.1021/acschembio.8b00978. [pdf] [html]

FEATURED "IN this issue" of THE March 2019 ISSUE OF ACS CHEMICAL BIOLOGY. [HTML]

41. Grenier, V.; Daws, B. R.; Liu, P; Miller, E. W.; Spying on neuronal membrane potential with genetically targetable voltage indicators. J Am Chem Soc. 2019, 141, 1349-58. DOI: 10.1021/jacs.8b11997. [pdf] [html]

40. Kulkarni, R. U.; Vandenberghe, M.; Thunemann, M.; James, F.; Andreassen, O. A.; Djurovic, S.; Devor, A.; Miller, E. W.; In Vivo Two-Photon Voltage Imaging with Sulfonated Rhodamine Dyes. ACS Cent Sci. 2018, 4, 1371-1378. DOI: 10.1021/acscentsci.8b00422. [pdf] [html]

39. McNamara H. M.; Dodson, S.; Huang, Y. L.; Miller, E. W.; Sandstede, B.; Cohen, A. E.; Geometry-Dependent Arrhythmias in Electrically Excitable Tissues. Cell Syst., 2018, 7, 359-370.e6. DOI: 10.1016/j.cels.2018.08.013. [pdf] [html]

38. Adil, M. M.; Gaj, T.; Rao, A. T.; Kulkarni, R. U.; Fuentes, C. M.; Ramadoss, G. N.; Ekman, F. K.; Miller, E. W.; Schaffer, D. V.; hPSC-Derived Striatal Cells Generated Using a Scalable 3D Hydrogel Promote Recovery in a Huntington Disease Mouse Model. Stem Cell Reports, 2018, 10, 1481. DOI: 10.1016/j.stemcr.2018.03.007. [pdf] [html]

37. Contractor, A. A. and Miller, E. W.; Imaging Ca2+ with a Fluorescent Rhodol. Biochemistry, 2018, 57, 237-40. DOI: 10.1021/acs.biochm.7b01050. [pdf] [html]

36. Liu, P; Grenier, V.; Hong, W.; Muller, V. R.; Miller, E. W.; "Fluorogenic Targeting of Voltage-Sensitive Dyes to Neurons", J Am Chem Soc, 2017, 139, 17334-40. DOI: 10.1021/jacs.7b07047. [pdf] [html]

35. McKeithan, W. L.; Savchenko, A; Yu, M. S.; Cerignoli, F.; Bruyneel, A. A. N.; Price, J. H.; Colas, A. R.; Miller, E. W.; Cashman, J. R.; Mercola, M.; An Automated Platform for Assessment of Congenital and Drug-Induced Arrhythmia with hiPSC-Derived Cardiomyocytes. Front Physiol 2017, 8, 766. DOI: 10.3389/fphys.2017.00766. [pdf] [html]

34. Kulkarni, R. U.; Miller, E. W.; "Voltage Imaging: Pitfalls and Potential." Biochemistry, 2017, 56, 5171-7. DOI: 10.1021/acs.biochem.7b00490 [pdf] [html]

33. Rodrigues, G. M. C.; Gaj, T.; Adil, M. M.; Wahba, J.; Rao, A. T.; Lorbeer, F. K.; Kulkarni, R. U.; Diogo, M. M.; Cabral, J. M. S.; Miller, E. W.; Hockemeyer, D.; Schaffer, D. V., "Defined and Scalable Differentiation of Human Oligodendrocyte Precursors from Pluripotent Stem Cells in a 3D Culture System" Stem Cell Reports, 2017, 8, 1770-83. DOI: 2017.10.1016/j.stemcr.2017.04.027 [pdf] [html]

32. Adil, M. M.; Vazin, T.; Ananthanarayanan B.; Rodrigues, G. M. C.; Rao, A. T.; Kulkarni, R. U.; Miller, E. W.; Kumar, S.; Schaffer, D. V.; "Engineered hydrogels increase the post-transplantation survival of encapsulated hESC-derived midbrain dopaminergic neurons," Biomaterials, 2017, 136, 1-11. DOI: 10.1016/j.biomaterials.2017.05.008. [pdf] [html]

31. *Knight, A. S.; *Kulkarni, R. U.; Zhou, E. Y.; Franke, J. M.; Miller, E. W.; Francis, M. B.; "A modular platform to develop peptoid-based selective fluorescent metal sensors," Chem Commun, 2017, 53, 3477-80. DOI: 10.1039/c7cc00931c. [pdf] [html]

30. *Kulkarni, R. U.; *Kramer, D. J.; Pourmandi, N.; Karbasi, K.; Bateup, H. S.; Miller, E. W.; “Voltage-sensitive rhodol with enhanced two-photon brightness,” Proc Natl Acad Sci USA 2017, 114 (11), 2813-8. DOI: 10.1073/pnas.1610791114. [pdf] [html]

Featured as a "Spotlight" in the April 2017 issue of ACS Chemical Biology. [html]

29. Adil, M. M.; Rodrigues, G. M. C.; Kulkarni, R. U.; Rao, A. T.; Chernavsky, N. E.; Miller, E. W.; Schaffer, D. V.; "Efficient generation of hPSC-derived midbrain dopaminergic neurons in a fully defined, scalable, 3D biomaterial platform." Sci Reports 2017, 7, 40573. DOI: 10.1038/srep40573. [pdf] [html]

28. Kulkarni, R. U.; Yin, H.; Pourmandi, N.; James, F.; Adil, M. M.; Schaffer, D. V.; Wang, Y.; Miller, E. W.; “A Rationally Designed, General Strategy for Membrane Orientation of Photoinduced Electron Transfer-Based Voltage-Sensitive Dyes.” ACS Chem Biol 2017, 12 (2), 407-13. DOI: 10.1021/acschembio.6b00981. [pdf] [html]

27.    Deal, P. E., Kulkarni, R. U., Al-Abdullatif, S. H., Miller, E. W., Isomerically pure tetramethylrhodamine voltage reporters. J Am Chem Soc 2016, 138 (29), 9085-8. DOI: 10.1021/jacs.6b05672. [pdf] [html]

featured as a "spotlight" in the August 24, 2016 issue of jacs. [html]

26.       Miller, E. W ., Small molecule fluorescent voltage indicators for studying membrane potential. Curr Opin Chem Biol, 2016, 33, 74-80. DOI: 10.1016/j.cbpa.2016.06.003. [pdf] [html]

25.       Grenier, V.; Walker, A. S.; Miller, E. W., A small-molecule photoactivatable optical sensor of transmembrane potential. J Am Chem Soc 2015, 137 (34), 10894-7. DOI: 10.1021/jacs.5b05538. [pdf] [html]

highlighted in Nature Methods editorial (Oct. 2015). [html]

24.       Huang, Y. L.; Walker, A. S.; Miller, E. W., A Photostable Silicon Rhodamine Platform for Optical Voltage Sensing. J Am Chem Soc 2015, 137 (33), 10767-76.  DOI: 10.1021/jacs.5b06644.  [pdf] [html]

selected as a "spotlight" publication for the Aug. 26, 2015 issue of jacs. [html]

23.       Miller, E. W., Chemical biologists rush to San Francisco for the ICBS. Nat Chem Biol 2015, 11, 91. [pdf] [html]

22.       Rubinstein, N.; Liu, P.; Miller, E. W.; Weinstain, R., meso-Methylhydroxy BODIPY: a scaffold for photo-labile protecting groups. Chem Commun 2015, 51, 6369. [pdf] [html]

21.       Woodford, C. R.; Frady, E. P.; Smith, R. S.; Morey, B.; Canzi, G.; Palida, S. F.; Araneda, R. C.; Kristan, W. B., Jr.; Kubiak, C. P.; *Miller, E. W.; *Tsien, R. Y., Improved PeT Molecules for Optically Sensing Voltage in Neurons. J Am Chem Soc 2015, 137, 1817. [pdf] [html]

20.         Dolensek, J.; Stozer, A.; Skelin Klemen, M.; Miller, E. W.; Slak Rupnik, M., The relationship between membrane potential and calcium dynamics in glucose-stimulated beta cell syncytium in acute mouse pancreas tissue slices. PLoS One 2013, 8, e82374. [pdf] [html]

19.         Moshtagh-Khorasani, M.; Miller, E. W.; Torre, V., The spontaneous electrical activity of neurons in leech ganglia. Physiol Rep 2013, 1, e00089. [pdf] [html]

18.         Miller, E. W.; Lin, J. Y.; Frady, E. P.; Steinbach, P. A.; Kristan, W. B.; Tsien, R. Y., Optically monitoring voltage in neurons by photo-induced electron transfer through molecular wires. Proc Natl Acad Sci U S A 2012, 109 (6), 2114-2119. [pdf] [html]

17.         Dodani, S. C.; Domaille, D. W.; Nam, C. I.; Miller, E. W.; Finney, L. A.; Vogt, S.; Chang, C. J., Calcium-dependent copper redistributions in neuronal cells revealed by a fluorescent copper sensor and X-ray fluorescence microscopy. Proc Natl Acad Sci U S A 2011, 108 (15), 5980-5. [pdf] [html]

16.         Miller, E. W.; Taulet, N.; Onak, C. S.; New, E. J.; Lanselle, J. K.; Smelick, G. S.; Chang, C. J., Light-Activated Regulation of Cofilin Dynamics Using a Photocaged Hydrogen Peroxide Generator. J Am Chem Soc 2010. [pdf] [html]

15.         Miller, E. W.; Dickinson, B. C.; Chang, C. J., Aquaporin-3 mediates hydrogen peroxide uptake to regulate downstream intracellular signaling. Proc Natl Acad Sci U S A 2010, 107 (36), 15681-6. [pdf] [html]

14.         Cheng, W. Y.; Tong, H.; Miller, E. W.; Chang, C. J.; Remington, J.; Zucker, R. M.; Bromberg, P. A.; Samet, J. M.; Hofer, T. P., An integrated imaging approach to the study of oxidative stress generation by mitochondrial dysfunction in living cells. Environ Health Perspect 2010, 118 (7), 902-8. [pdf]

13.         Bao, L.; Avshalumov, M. V.; Patel, J. C.; Lee, C. R.; Miller, E. W.; Chang, C. J.; Rice, M. E., Mitochondria are the source of hydrogen peroxide for dynamic brain-cell signaling. J Neurosci 2009, 29 (28), 9002-10. [pdf] [html]

12.         Srikun, D.; Miller, E. W.; Domaille, D. W.; Chang, C. J., An ICT-based approach to ratiometric fluorescence imaging of hydrogen peroxide produced in living cells. J Am Chem Soc 2008, 130 (14), 4596-7. [pdf] [html]

11.         Miller, E. W.; He, Q.; Chang, C. J., Preparation and use of Leadfluor-1, a synthetic fluorophore for live-cell lead imaging. Nat Protoc 2008, 3 (5), 777-83. [pdf] [html]

10.         Albers, A. E.; Dickinson, B. C.; Miller, E. W.; Chang, C. J., A red-emitting naphthofluorescein-based fluorescent probe for selective detection of hydrogen peroxide in living cells. Bioorg Med Chem Lett 2008, 18 (22), 5948-50. [pdf] [html]

9.       Yoon, S.; Miller, E. W.; He, Q.; Do, P. H.; Chang, C. J., A bright and specific fluorescent sensor for mercury in water, cells, and tissue. Angew Chem Int Ed Engl 2007, 46 (35), 6658-61. [pdf] [html]

8.       Miller, E. W.; Tulyathan, O.; Isacoff, E. Y.; Chang, C. J., Molecular imaging of hydrogen peroxide produced for cell signaling. Nat Chem Biol 2007, 3 (5), 263-7. [pdf] [html]

7.       Miller, E. W.; Chang, C. J., Fluorescent probes for nitric oxide and hydrogen peroxide in cell signaling. Curr Opin Chem Biol 2007, 11 (6), 620-5. [pdf] [html]

6.       Miller, E. W.; Bian, S. X.; Chang, C. J., A fluorescent sensor for imaging reversible redox cycles in living cells. J Am Chem Soc 2007, 129 (12), 3458-9. [pdf] [html]

5.       Zeng, L.; Miller, E. W.; Pralle, A.; Isacoff, E. Y.; Chang, C. J., A selective turn-on fluorescent sensor for imaging copper in living cells. J Am Chem Soc 2006, 128 (1), 10-1. [pdf] [html]

4.       Miller, E. W.; Zeng, L.; Domaille, D. W.; Chang, C. J., Preparation and use of Coppersensor-1, a synthetic fluorophore for live-cell copper imaging. Nat Protoc 2006, 1 (2), 824-7. [pdf]

3.       He, Q.; Miller, E. W.; Wong, A. P.; Chang, C. J., A selective fluorescent sensor for detecting lead in living cells. J Am Chem Soc 2006, 128 (29), 9316-7. [pdf] [html]

2.       Miller, E. W.; Albers, A. E.; Pralle, A.; Isacoff, E. Y.; Chang, C. J., Boronate-based fluorescent probes for imaging cellular hydrogen peroxide. J Am Chem Soc 2005, 127 (47), 16652-9. [pdf] [html]

1.       Heasley, V. L.; Fisher, A. M.; Herman, E. E.; Jacobsen, F. E.; Miller, E. W.; Ramirez, A. M.; Royer, N. R.; Whisenand, J. M.; Zoetewey, D. L.; Shellhamer, D. F., Investigations of the reactions of monochloramine and dichloramine with selected phenols: examination of humic acid models and water contaminants. Environ Sci Technol 2004, 38 (19), 5022-9. [pdf]